Hemophilia
Retrovirus-based induction of clotting factor IX corrects hemophilia B
Published in Gene Therapy Weekly, September 25th, 2003
"Recombinant AAV particles of high titer (>1013 virus genome/mL) were prepared according to the rHSV/AAV helper virus method. After intramuscular injection of viral vectors in the hind limb, a sustained elevated level (>370 ng/mL) of murine FIX expression in the plasma of hemophilia B mouse was detected and persisted for more than 350 days. The biological activity reached 30% of normal levels, and bleeding symptoms in the treated mice were significantly alleviated," scientists in the People's Republicepublic of China reported.
"No anti-FIX antibody...
Want to see the full article?
We're a pay-per-view site for premium content. If you'd like to purchase this article, it's only $3.00.
Welcome to NewsRx!
Learn more about a six-week, no-risk free trial of Gene Therapy Weekly
Source: Gene Therapy Weekly (2003-09-25)
More Articles from Gene Therapy Weekly
- Virology
Viral combinations enhance the antitumor effect of interleukin-12 gene therapy - Enzymology
Timing is key to gene-directed therapy and cancer cell sensitivity - Transplant Medicine
Retrovirus-based selection makes cells more resistant to cytotoxin - Vector Development
Electroporation and gene therapy arrest EBV-mediated cancer in tumor models - Weight Reduction
Hydrodynamics augments leptin gene expression and increases weight loss in mice - Cloning Research
Grant renews funding of research toward cloning primates - More from this issue of Gene Therapy Weekly
NewsRx is Social
Follow us on your favorite social network by clicking on a button below:
Top Medical Newsletters
Awards
Best Health/Healthcare Content, 2012
Best Health/Healthcare Content, 2011
Best e-Business Site, 2010
Best e-Business Site, 2009
Best e-Business Site, 2008
Best e-Business Site, 2007
Best e-Business Site, 2006
Best Healthcare Content, 2005
Best Overall Internet Site, 2005
Best Interactive Site, 2005
Facts & Stats
NewsRx also is available at LexisNexis, Gale, ProQuest, Factiva, Dialog, Thomson Reuters, NewsEdge, and Dow Jones.
- Google 2010 PageRank: #2 Among Top Health News and Media Publications
- Google 2010 PageRank: #2 Among Top Science Publications in Biology/Physiology
- Google 2010 PageRank: #2 Among Top News and Media for the Business of Pharmaceuticals
- Amazon's Alexa 2010 PageRank: #2 News and Media Site for the Pharmaceutical Industry
