Oncology
Intrabody-based strategies might inhibit angiogenesis and tumor growth
Published in Gene Therapy Weekly, September 25th, 2003
"VEGF, an endothelial-specific mitogen, is an important tumor angiogenesis growth factor. The major receptor for VEGF on endothelial cells is KDR. We hypothesized that an intrabody could bind newly synthesized KDR and block receptor transport to the cell surface, thereby inhibiting important VEGF effects," scientists writing in the FASEB Journal report.
"We expressed a single chain antibody (p3S5) to KDR with or without the endoplasmic reticulum (ER) retention signal (KDEL), using either a plasmid (p3S5-HAK) or a tet-off adenoviral system (Ad-HAK). Plasmid-mediated...
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Source: Gene Therapy Weekly (2003-09-25)
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