Vaccine Development
Dendritic cells become more effective after interleukin-2 transfection
Published in Gene Therapy Weekly, September 25th, 2003
According to a study from Australia, "dendritic cell (DC) therapies using DC presenting tumor antigen/s can induce CD8(+) CTL that mediate tumor eradication, nonetheless many patients remain unresponsive. Thus, cytokine gene vectors applied to DC may amplify these responses. Herein, we examined the responses that monocyte-derived DC (at different maturational stages) make when infected with a vaccinia virus-interleukin-2 (VV-IL-2) vector in vitro."
"MIL-2-infected DC secreted significant levels of bioactive IL-2 and maintained their antigen presentation function. However, we show...
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Source: Gene Therapy Weekly (2003-09-25)
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