Virology
Recombinant Sendai virus vectors can transduce activated T lymphocytes
Published in Gene Therapy Weekly, September 25th, 2003
"T-lymphocyte-directed gene therapy has potential as a treatment of subjects with immunological disorders. One current limitation of this therapeutic strategy is low gene transfer efficiency, even when complex procedures are used. We report herein that a recombinant Sendai virus vector (SeV) was able to overcome this issue," scientists in Japan stated.
"Using jellyfish enhanced green fluorescent protein gene (EGFP), we found that SeV was able to transduce and express a foreign gene specifically and efficiently in activated murine and human T cells, but not in naive T cells,...
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Source: Gene Therapy Weekly (2003-09-25)
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