Enzymology
Timing is key to gene-directed therapy and cancer cell sensitivity
Published in Gene Therapy Weekly, September 25th, 2003
According to recent research published in the journal Cancer Gene Therapy, "cytochrome P450-based gene therapy can substantially increase the sensitivity of tumor cells to P450-activated cancer chemotherapeutic prodrugs such as cyclophosphamide (CPA) without increasing host toxicity."
"While the role of 4-OH-CPA, the primary active metabolite of CPA, in eliciting tumor cell death is well established, the effect of 4-OH-CPA exposure on the capacity of P450-expressing tumor cells for continued metabolism and activation of CPA has not been investigated. The present study...
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Source: Gene Therapy Weekly (2003-09-25)
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