Gene Therapy Toxicity

"Stop leak" solution found for problems in experiments with mice

Published in Gene Therapy Weekly, October 2nd, 2003

A Duke University research collaboration has identified a likely route for "leakage" of therapeutic gene-bearing viruses out of tumors in experimental anticancer gene therapy experiments in laboratory animals.

The group also found this toxic leakage can be avoided by using a chemical extracted from common brown algae.

Their work was described in a presentation at the American Chemical Society's national meeting in New York, as well as in a research paper accepted for publication in the journal Molecular Cancer Therapeutics.

Investigators from the biomedical engineering department at Duke's Pratt School of Engineering and...

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Source: Gene Therapy Weekly (2003-10-02)

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