Gene Transfer

Coated stents deliver gene therapy to specific locales

Published in Gene Therapy Weekly, October 2nd, 2003

Coated stents deliver gene therapy to specific locales.

"We previously demonstrated that DNA-polylactic-polyglycolic acid (PLGA)-coated stents can deliver genes to the arterial wall with reporter expression involving 1% of neointimal cells. The present study investigated a novel formulation utilizing denatured collagen in DNA-stent coatings; denatured collagen was hypothesized to enhance gene transfer due to adhesion molecule interactions and actin-related mechanisms. Arterial smooth muscle cells (SMCs) cultivated on denatured collagen had significantly greater plasmid DNA (beta-galactosidase) transfection than SMC grown on native collagen (18.3±1.2 vs....

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Source: Gene Therapy Weekly (2003-10-02)

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