Enzymology
Glucose-6-phosphate dehydrogenase modulates VEGF-induced angiogenesis
Published in Gene Therapy Weekly, October 9th, 2003
"Glucose-6-phosphate dehydrogenase (G6PD), the first enzyme of the pentose phosphate pathway, is the principal intracellular source of NADPH. NADPH is utilized as a cofactor by vascular endothelial cell nitric-oxide synthase (eNOS) to generate nitric oxide (NO)," scientists writing in the Journal of Biological Chemistry say.
"To determine whether G6PD modulates NO-mediated angiogenesis, we decreased G6PD expression in bovine aortic endothelial cells using an antisense oligodeoxynucleotide to G6PD or increased G6PD expression by adenoviral gene transfer, and we examined...
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Source: Gene Therapy Weekly (2003-10-09)
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