Cirrhosis
Hepatocyte growth factor gene delivery attenuates liver disease
Published in Gene Therapy Weekly, October 9th, 2003
"Although a variety of gene transfer methods to the liver have been designed, there are some problems such as the transfection efficiency and safety. In the present study, we developed a modified method of gene transfer into the liver by infusion of plasmid DNA via the portal vein followed by electroporation. After green fluorescence protein gene transfer, transgene expressions were detected in 24 hours, and then maximally at 3 days, and persisted for 3 weeks," according to published research from Japan.
"Histological analysis revealed that very mild tissue damage was induced in the...
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Source: Gene Therapy Weekly (2003-10-09)
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