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Oncogenesis

Human prostate cancers lack evidence of KLF6 tumor suppressor gene mutations

Published in Gene Therapy Weekly, October 9th, 2003

Human prostate cancers lack evidence of KLF6 tumor suppressor gene mutations.

According to recent research published in the British Journal of Cancer, "a recent report suggests that the KLF6 gene encoding the Kruppel-like factor 6 protein is a frequently mutated, putative tumor suppressor gene in prostate cancer. The aims of the present study were to confirm these initial findings by determining the frequency of exon2 KLF6 mutations in a cohort of European prostate cancer patients, and to investigate whether there was evidence for mutational inactivation of both the KLF6 and TP53 tumor suppressor loci in some tumors."

"We examined 32 primary...

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