Published in Gene Therapy Weekly, October 16th, 2003
"Diffuse astrocytoma of World Health Organization (WHO) grade H has an inherent tendency to spontaneously progress to anaplastic astrocytoma (WHO, grade in) and/or glioblastoma (WHO grade IV). The molecular basis of astrocytoma progression is still poorly understood, in particular with respect to the progression-associated changes at the mRNA level.
"Therefore, we compared the transcriptional profile of approximately 6800 genes in primary WHO grade H gliomas and corresponding recurrent high-grade (WHO grade III or IV) gliomas from eight patients using...
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