Shortened adenovirus fiber shafts hamper postinfection activity

According to recent research from France, "the coxsackie B virus and adenovirus receptor (CAR) functions as an attachment receptor for multiple adenovirus serotypes. It has been shown that apart from virus-cellular receptor interactions, the fiber shaft length also influences viral tropism. We therefore generated Ad5FbDelta639 virus with 8beta-repeats in the shaft, instead of the 22beta-repeats present in the wild-type."

"Here, we show that the extent of attachment of the virus with shortened fiber to CAR-expressing cells was three- to fivefold lower than that of the wild-type....

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