Neuroscience
Gene-modified cells correct Parkinson-like disease in animal models
Published in Gene Therapy Weekly, October 16th, 2003
According to published research from the People's Republic of China, "eukaryotic plasmid vectors encoding the tyrosine hydroxylase (TH) gene and GTP cyclohydrolase-1 (GCH) gene were constructed and introduced into immortalized fibroblasts obtained from SV40 large antigen (LTAG) transformed rat primary fibroblasts. TH and GCH positive clones were selected and identified by immunohistochemistry and RT-PCR, respectively. Hemi-Parkinsonian rats created using 6-hydroxydopamine (6-OHDA) were used to assess the therapeutic effect created by the co-implantation of immortalized fibroblasts genetically modified...
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Source: Gene Therapy Weekly (2003-10-16)
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