Published in Gene Therapy Weekly, October 16th, 2003
"CD437, a novel retinoid, causes cell cycle arrest and apoptosis in a number of cancer cells including human breast carcinoma (HBC) by utilizing an undefined retinoic acid receptor/retinoid X receptor-independent mechanism. To delineate mediators of CD437 signaling, we utilized a random antisense-dependent functional knockout genetic approach. We identified a cDNA that encodes approximately 130- kDa HBC cell perinuclear protein (termed CARP-1)," scientists in the United States report.
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