Colon Cancer
Adenovirus-mediated transduction enhances radiosensitivity in colon cancer
Published in Gene Therapy Weekly, October 23rd, 2003
"Nuclear factor kappa B (NF-kappaB) is a transcription factor that is known to regulate apoptosis when cells are exposed to DNA-damaging agents such as ionizing radiation and cytotoxic drugs. We sought to determine if inhibition of NF-kappaB could enhance radiosensitivity in human colon cancer cells in vitro and in vivo. To inhibit NF-kappaB activation specifically, we constructed a recombinant adenovirus vector expressing a truncated form of the inhibitor protein IkappaBalpha (IkappaBalphaDeltaN) that lacks the phosphorylation sites essential for activation of NF-kappaB, and transfected two...
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Source: Gene Therapy Weekly (2003-10-23)
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