Colon Cancer
Lipoplexes containing interferon genes and poly I:poly C halt metastasis
Published in Gene Therapy Weekly, October 23rd, 2003
"We have evaluated and compared the efficacy of systemic administration of lipoplex formulations containing plasmids encoding IFN-beta or IFN-gamma, and a synthetic double-strand RNA poly I: poly C (pI: pC), a type I IFN inducer, in a lung metastasis model in which colon carcinoma CT-26 cells were inoculated intravenously into immunocompatible mice," according to F. Sakurai and colleagues, Kyoto University, Graduate School of Pharmaceutical Science.
"Injection of lipoplexes containing plasmid DNA, regardless of IFN gene insertion, stimulated a transient increase in the serum...
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Source: Gene Therapy Weekly (2003-10-23)
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