Oncology
New cancer gene therapy restricts treatment to liver cancer cells
Published in Gene Therapy Weekly, October 23rd, 2003
"Suicide gene therapy combining herpes simplex virus thymidine kinase gene transfer and ganciclovir administration can be envisioned as a powerful therapeutical approach in the treatment of hepatocellular carcinoma; however, safety issues regarding transgene expression in parenchyma cells have to be addressed," researchers in France stated.
"In this study, we constructed LATKW, a lentiviral vector expressing the HSV-TkEGFP gene placed under the control of the promoter elements that control the expression of the rat alpha-fetoprotein, and assayed its specific expression in vitro in...
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Source: Gene Therapy Weekly (2003-10-23)
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