Rheumatology
Gene transfer in SCID mice provides a new way to assess disease models
Published in Gene Therapy Weekly, October 30th, 2003
"The hallmark of rheumatoid arthritis (RA) is progressive destruction of the joints, preceded and accompanied by synovial hyperplasia and chronic inflammation. Spontaneous and induced animal models of RA reflect predominantly the inflammatory aspects of the disease. To reproduce the destruction of cartilage and bone mediated by an activated synovium, it was desirable to develop models that allow the dissection of cellular and molecular components derived from human tissue," scientists in Switzerland reported.
"The SCID mouse co-implantation model of human RA focuses on RA...
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Source: Gene Therapy Weekly (2003-10-30)
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