Published in Gene Therapy Weekly, October 30th, 2003
"We have been developing a new gene delivery method using a styrenated gelatin-based tissue-adhesive matrix that allows in situ adenovirus-immobilized gel formation on living tissue and sustained virus release to permeate carcinoma tissue. Styrenated gelatin was synthesized by the condensation reaction of gelatin with 4-vinylbenzoic acid. Aqueous styrenated gelatin solution premixed with AdLacZ, adenovirus encoding beta-galactosidase cDNA, and carboxylated camphorquinone (CQ) as a photoinitiator was irradiated with visible light to form a styrenated gelatin gel," according to researchers in...
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