Head and Neck Cancer
Adenovirus-mediated p16 gene therapy combats radiation-resistant cancer cells
Published in Gene Therapy Weekly, October 30th, 2003
"Since adenoviral p16(INK4A) gene transfer has shown limited promise in preclinical studies, we developed a strategy combining ionizing radiation (x-rays) with Ad-p16 gene therapy. Both radiation (2 Gy) and Ad-p16 alone demonstrated anti-tumor responses. The combination of radiation and Ad-p16 in vitro showed an augmented therapeutic response," scientists in the United States reported.
"Two head and neck squamous cell carcinoma (HNSCC) cell lines treated with Ad-p16 demonstrated positive staining to annexin V and terminal deoxynucleotidyl-transferase, suggesting apoptosis....
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Source: Gene Therapy Weekly (2003-10-30)
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