Gene Transfer
Human serum albumin-polyethylenimine nanoparticles power transfection ability
Published in Gene Therapy Weekly, November 13th, 2003
According to recent research from Germany, "nanoparticles consisting of DNA, human serum albumin (HSA) and polyethylenimine (PEI) were formed and tested for transfection efficiency in vitro with the aim of generating a nonviral gene delivery vehicle."
"HSA-PEI-DNA nanoparticles containing the pGL3 vector coding for luciferase as reporter gene were formed by charge neutralization. The particles were characterized by gel retardation assay, dynamic light scattering (size) and electrophoretic mobility measurements (charge)," described S. Rhaese and colleagues, University of...
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Source: Gene Therapy Weekly (2003-11-13)
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