Published in Gene Therapy Weekly, November 13th, 2003
"Routine clinical implementation of human gene therapy awaits safe and efficient gene delivery methods. Polymeric vectors hold promise due to the availability of diverse chemistries, potentially providing targeting, low immunogenicity, nontoxicity, and robustness, but lack sufficient gene delivery efficiency," according to investigators in the United States.
"We have synthesized a versatile group of degradable polycations through the addition of 800-Da polyethylenimine (PEI) to small diacrylate cross-linkers," stated M.L. Forrest and colleagues, University of Illinois, Department of...
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