Biosynthesis
New RNase P ribozymes are feasible for use in gene-targeting applications
Published in Gene Therapy Weekly, November 13th, 2003
"Ribonuclease P (RNase P) is a ubiquitous ribonucleoprotein complex responsible for the biosynthesis of tRNA. This enzyme from Escherichia coli contains a catalytic RNA subunit (M1 ribozyme) and a protein subunit (C5 cofactor). M1 ribozyme cleaves an RNA helix that resembles the acceptor stem and T-stem structure of its natural tRNA substrate," scientists writing in the journal Gene report.
"When covalently linked with a guide sequence, M1 RNA can be engineered into a sequence-specific endonuclease, M1GS ribozyme, which can cleave any target RNA sequences that...
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Source: Gene Therapy Weekly (2003-11-13)
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