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Immunology

Ischemia, alloantigen, and gene transfer induce cardiac genes differentially

Published in Gene Therapy Weekly, December 4th, 2003

Ischemia, alloantigen, and gene transfer induce cardiac genes differentially.

"Transplantation of allogeneic grafts presents several challenges to the innate and adaptive immune systems including chemokine leukocyte recruitment, activation, and effector function. We defined the chemokines and receptors induced by the transplant procedure/ischemia injury, alloantigen and gene transfer vector administration in murine cardiac grafts. E1 E3 deleted AdRSVPgal was transferred into grafts at the time of transplantation, grafts were harvested after 1-14 days, and a pathway-specific cDNA array was used to evaluate the levels of 67 chemokine and chemokine receptor genes,"...

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