Published in Gene Therapy Weekly, December 4th, 2003
"Short-lived gene expression elements (GEE) represent currently a significant obstacle for gene therapy. To identify GEE such as promoters, enhancers, locus control regions, or insulators useful for long-term or tissue-specific gene therapy, we developed a GEE trapping strategy in which any sequence can be screened for activity in vivo and the expressing clones can be rapidly isolated. Test sequences are introduced into a herpesvirus (HSV) amplicon vector that expresses green fluorescent protein (GFP) only if the insert has GEE function," scientists in the United States explained.
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