Gene Transfer

A novel amplicon system identifies obstacles to new therapies

Published in Gene Therapy Weekly, December 4th, 2003

A novel amplicon system identifies obstacles to new therapies.

"Short-lived gene expression elements (GEE) represent currently a significant obstacle for gene therapy. To identify GEE such as promoters, enhancers, locus control regions, or insulators useful for long-term or tissue-specific gene therapy, we developed a GEE trapping strategy in which any sequence can be screened for activity in vivo and the expressing clones can be rapidly isolated. Test sequences are introduced into a herpesvirus (HSV) amplicon vector that expresses green fluorescent protein (GFP) only if the insert has GEE function," scientists in the United States explained.

"The...

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Source: Gene Therapy Weekly (2003-12-04)

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