Cardiology
Murine models predict the gene profiles and phenotype of heart disease
Published in Gene Therapy Weekly, December 11th, 2003
According to recent research from the United States, "numerous murine models of heart failure (HF) have been described, many of which develop progressive deterioration of cardiac function. We have recently demonstrated that several of these can be ''rescued'' or prevented by transgenic cardiac expression of a peptide inhibitor of the beta-adrenergic receptor kinase (betaARKct). To uncover genomic changes associated with cardiomyopathy and/or its phenotypic rescue by the betaARKct, oligonucleotide microarray analysis of left ventricular (LV) gene expression was performed in a total of 53 samples,...
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Source: Gene Therapy Weekly (2003-12-11)
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