Enzymology
Suicide gene therapy bystander effects correlate with cell communication
Published in Gene Therapy Weekly, December 11th, 2003
"Gap junctional intercellular communication (GJIC) has been shown to be involved in the bystander effect through herpes simplex virus thymidine kinase/ganciclovir (HSV-tk/GCV) gene therapy. In this study, we examined the expression of connexins, the components of gap junction, and the degree of GJIC in esophageal cancer cell lines and compared the bystander effect in cells with different capacities of GJIC. We found loss in connexin 26 expression and reduced connexin 43 in esophageal cancer," investigators in Japan report.
"GJIC capacity varied among cell lines and was...
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Source: Gene Therapy Weekly (2003-12-11)
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