Gene Suppression
E2F decoy oligodeoxynucleotides block human tumor cell growth
Published in Gene Therapy Weekly, December 11th, 2003
"Abnormal cell proliferation, largely dependent upon deregulation of cell-cycle regulatory proteins, is an important feature of several forms of human cancer. The transcription factor, E2F, plays a critical role in the trans-activation of several genes involved in cell-cycle regulation, thereby regulating cell growth," according to scientists writing in the journal Biochemical and Biophysical Research Communications.
"We have demonstrated that E2F decoy oligodeoxynucleotides (ODNs) with a circular dumbbell structure (CD-E2F decoy) corresponding to E2F binding sites effectively...
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Source: Gene Therapy Weekly (2003-12-11)
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