Pain Medicine
CREB phosphorylation is central to the pathogenesis of neurotrophic pain
Published in Gene Therapy Weekly, December 11th, 2003
"The transcription factor cAMP responsive element binding protein (CREB) is important in regulating immediate-early genes and some late-effector genes involved in neuroplasticity in response to peripheral injury and stressful insults. Partial nerve injury elicited neuropathic pain is accompanied by increased phosphorylation of CREB in the ipsilateral spinal cord dorsal horn (Ma et al., Pain, 2001;93:295 and Miletic et al., Pain, 2002;99:493)," scientists in the United States report.
"The aim of this study is to determine whether increased phosphorylation of CREB in the dorsal...
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Source: Gene Therapy Weekly (2003-12-11)
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