Enzymology
Nontoxic radiolabeled molecules monitor vector distribution
Published in Gene Therapy Weekly, December 25th, 2003
According to recent research published in the journal Gene Therapy, "herpes simplex virus thymidine kinase (HSV-TK) is widely used in gene therapy. The enzymatic activity of HSV-TK may be traced in vivo by specific radiopharmaceuticals in order to image transgene expression. However, most of these radiopharmaceuticals are toxic per se or after activation by HSV-TK, and therefore do not represent ideal molecules for clinical applications and repeated imaging."
"Unlike human cytosolic TK, HSV-TK is not enantioselective and can efficiently phosphorylate both D and L enantiomers of...
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Source: Gene Therapy Weekly (2003-12-25)
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