Gene Expression

Optimized adenovirus directs genes to designated cells

Published in Gene Therapy Weekly, January 8th, 2004

Optimized adenovirus directs genes to designated cells.

"Gene expression-based imaging coupled to gene therapy will permit the prediction of therapeutic outcome. A significant challenge for successful gene therapy is to achieve a high-level of specific gene expression; however, tissue-specific promoters are weak. We postulate that if the weak activity of tissue-specific promoters can be amplified to the levels of strong viral promoters, which have been successful in preclinical scenarios, while retaining specificity, the therapeutic index of gene therapy can be greatly augmented," researchers in the United States report.

"With this in mind, we...

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Source: Gene Therapy Weekly (2004-01-08)

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