Oncology
Many factors affect how oncolytic adenoviruses transfect tumors
Published in Gene Therapy Weekly, January 8th, 2004
"Avoiding transduction of normal tissue after intravenous application of oncolytic adenoviruses (Ad) is an important strategy to improve the safety and efficacy of these vectors in gene therapy. As a model for a targeted vector, we used Ad vectors with type 35 fibers (Ad5/35), which efficiently transduce human cervical carcinoma cells but not liver cells," wrote scientists in the United States.
"In an in vitro model of liver metastases, in which small nests of HeLa cells were surrounded by mouse hepatocytes, we showed that an Ad5/35-based conditionally replicating vector regulated by...
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Source: Gene Therapy Weekly (2004-01-08)
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