Vector Development
Micelle formation is key to how chlorpromazine augments retroviral transduction
Published in Gene Therapy Weekly, January 8th, 2004
"Retrovirus packaging cell lines that express the Moloney murine leukemia virus gag, pol, and env genes and a retroviral vector genome can produce virus particles that are capable of transducing cells. Normally if the packaging cell line does not produce a functional viral fusion glycoprotein, such as the retroviral envelope protein or a foreign viral glycoprotein, then the viruses will be incapable of transducing cells. We have found that incubating envelope protein-deficient virus particles bound to cells with chlorpromazine leads to transduction," investigators in the United States...
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Source: Gene Therapy Weekly (2004-01-08)
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