Neuroscience
Antisense constructs evaluate N-methyl-D-aspartate receptor action
Published in Gene Therapy Weekly, January 29th, 2004
According to a study from Canada, "the N-methyl-D-aspartate receptor (NMDAR) is a major neurotransmitter receptor in the central nervous system (CNS), with functional roles in learning, memory, and sensation. Several mechanisms potentiate NMDARs, and NMDAR hyperexcitability plays pathophysiological roles in many conditions, such as neurodegenerative disease, ischemia, and chronic conditions arising from spinal cord injury. Previous research suggests that the NR2A subunit of the receptor contributes to NMDAR excitotoxicity in heterologous cells and in neurons in vivo."
"To investigate...
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Source: Gene Therapy Weekly (2004-01-29)
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