Pertussis Vaccine
DNA vaccine encoding pertussis toxin S1 subunit induces protection
Published in Gene Therapy Weekly, January 29th, 2004
According to a study from Japan, "Pertussis toxin (PT) is the major virulence factor of Bordetella pertussis, and detoxified PT is a crucial antigen of acellular pertussis vaccine. Here, plasmid DNA expressing the pertussis toxin S1 subunit (pcDNA/S1) of B. pertussis was evaluated for immunogenicity and for the ability to induce protection against PT challenge or B. pertussis infection in mice."
"The gene gun delivery of pcDNA/S1, performed by inserting the S1 gene into a mammalian expression vector, successfully...
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Source: Gene Therapy Weekly (2004-01-29)
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