Vector Development
Electroporation facilitates gene transfer into adult skeletal muscle myofibers
Published in Gene Therapy Weekly, February 12th, 2004
"The postmitotic nature and longevity of skeletal muscle fibers permit stable expression of any transfected gene. Direct in vivo injection of plasmid DNA, in both adult and regenerating muscles, is a safe, inexpensive, and easy approach. Here we present an optimized electroporation protocol based on the use of spatula electrodes to transfer cDNA in vivo into the adult myofibers of an anatomically defined muscle, which could be functionally characterized," scientists writing in the journal Biochemical and Biophysical Research Communications stated.
"In our hands,...
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Source: Gene Therapy Weekly (2004-02-12)
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