Oncology
CHFR predicts the sensitivity of gastric cancer to microtubule inhibitors
Published in Gene Therapy Weekly, February 19th, 2004
"Mitotic checkpoints prevent errors in chromosome segregation that can lead to neoplasia. Therefore, it is notable that gastric cancers often show impaired checkpoint function. In the present study, we examined the functional consequences of epigenetic inactivation of the mitotic checkpoint gene CHFR (checkpoint with forkhead-associated and ring finger) in gastric cancers," scientists in Japan report.
"CHFR expression was silenced by DNA methylation of the 5' region of the gene in 20% of the gastric cancer cell lines tested and in 39% of primary gastric cancers; expression...
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Source: Gene Therapy Weekly (2004-02-19)
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