Drug Resistance
Restored caspase expression may resensitize lung cancer cells to chemotherapy
Published in Gene Therapy Weekly, February 26th, 2004
"Non small-cell lung carcinoma (NSCLC) is a highly lethal malignancy that often becomes resistant to chemotherapy. To determine whether alterations in apoptotic signaling might contribute to such resistance, we established in vitro and in vivo models for sensitive and resistant human NSCLC. We found that resistance is due to multiple defects found in expression of CD95-L, CD95 and members of the Bcl-2 and IAP family, as well as caspase-8, -9 and -3 as examined by immunohistochemistry, Western blot analysis, gene array analysis and functional assays," scientists in Germany report.
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Source: Gene Therapy Weekly (2004-02-26)
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