Antisense Technology
Self-assembled micelles shepherd antisense oligonucleotides to cancer cells
Published in Gene Therapy Weekly, February 26th, 2004
"The conjugate of antisense c-raf oligonucleotide (ODN) and poly(ethylene glycol) (PEG) was synthesized for intracellular ODN delivery. When combined with polyethylenimine (PEI), the ODN-PEG conjugate self-associated to form polyelectrolyte complex micelles in aqueous solution. The effective hydrodynamic diameter of the micelles was around 70 nm with a narrow size distribution," reported J.H. Jeong and colleagues, Korea Advanced Institute of Science & Technology, Department of Biological Sciences.
"Flow cytometry analysis indicated that the cellular uptake of the micelles by...
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Source: Gene Therapy Weekly (2004-02-26)
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