Endocrinology
Alpha-1 antitrypsin gene therapy prevents type I diabetes in NOD mice
Published in Gene Therapy Weekly, March 4th, 2004
According to a study from the United States, "type I diabetes results from an autoimmune destruction of the insulin-producing pancreatic beta cells. Although the exact immunologic processes underlying this disease are unclear, increasing evidence suggests that immunosuppressive, immunoregulatory and anti-inflammatory agents can interrupt the progression of the disease. Alpha-1 antitrypsin (AAT) is a multifunctional serine proteinase inhibitor (serpin) that also displays a wide range of anti-inflammatory properties."
"To test the ability of AAT to modulate the development of type I...
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Source: Gene Therapy Weekly (2004-03-04)
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