Gene Silencing
Retrovirus vector-delivered RNA interference downregulates gene expression
Published in Gene Therapy Weekly, March 4th, 2004
"RNA interference (RNAi) is the mechanism of sequence-specific, post-transcriptional gene silencing initiated by short interfering RNAs (siRNAs) homologous to the gene being suppressed. siRNAs, which mediate sequence-specific mRNA degradation, are duplexes of about 21-23 nucleotides with 3'-overhangs synthesized in vitro or expressed by DNA-based vector. However, these systems rely on transfection for delivery and cannot generate long-term gene silencing in vivo," researchers in the People's Republic of China report.
"This obstacle may be circumvented by recently developed...
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Source: Gene Therapy Weekly (2004-03-04)
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