Colon Cancer
A dominant-negative mutant of the c-Jun gene stems colorectal cancer growth
Published in Gene Therapy Weekly, March 4th, 2004
"Activator protein-1 (AP-1), a transcription factor, is activated through many oncogenic signals. However, its biological role in colorectal cancer has not been fully elucidated. To investigate the role of AP-1 in colorectal cancer, we constructed an adenovirus-expressing TAM67, a dominant-negative mutant of c-Jun lacking the transactivation domain of wild c-Jun (DN-c-Jun), to inhibit endogenous AP-1," researchers in Japan report.
"AP-1 DNA-binding activity was increased in colon cancer cells (HT-29 cells) by serum stimulation, followed by an increase in both...
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Source: Gene Therapy Weekly (2004-03-04)
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