Oncology
5-Fluorocytosine increases the toxicity of oncolytic viruses
Published in Gene Therapy Weekly, March 4th, 2004
"Clinical studies with oncolytic adenoviruses have shown that existing viruses are safe but lack efficacy. To selectively increase the toxicity of oncolytic adenoviruses targeting colon tumors, we have inserted the yeast cytosine deaminase gene (yCD) after the fiber gene in the major late transcript. yCD was expressed using either an internal ribosome entry site (IRES) or by alternative splicing of a new exon analogous to the Ad41 long fiber exon," scientists in Switzerland report.
"The IRES-CD virus gave higher yCD expression on Western blots. Both approaches result in yCD expression...
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Source: Gene Therapy Weekly (2004-03-04)
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