Gene Transfer

Insulin gene nasal inoculations improve diabetes in insulin-dependent models

Published in Gene Therapy Weekly, March 11th, 2004

Insulin gene nasal inoculations improve diabetes in insulin-dependent models.

"The present study examined the feasibility of liposome-mediated gene transfer via nasal administration for treating insulin-dependent diabetes mellitus. The rat insulin gene was packed under control of the cytomegalovirus (CMV) promoter, complexed with DC-chol/DOPE-based liposomes, and administered daily via the nasal route in mice made severely diabetic by streptozocin," said S. Tanaka and colleagues, Yokohama City University, School of Medicine.

"Sustained expression of the insulin gene was achieved and insulinopenia, ketonuria and death were prevented," researchers...

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Source: Gene Therapy Weekly (2004-03-11)

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