Immunology
Autoimmune tendencies spark inflated immune response to adeno-associated virus
Published in Gene Therapy Weekly, March 11th, 2004
According to recent research published in the journal Gene Therapy, "adeno-associated virus (AAV) is widely considered a promising vector for therapeutic gene delivery. This promise is based on previous studies assessing AAVs safety and toxicity, ability to infect nondividing cells, elicit a limited immune response, and provide long-term gene expression. However, we now find that earlier studies underappreciated the degree of AAV immunogenicity as well as the extent to which genetic background, through regulation of immune responsiveness, influences the duration of gene expression and...
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Source: Gene Therapy Weekly (2004-03-11)
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