Antisense Technology
New lipophilic cation conjugates direct antisense agents to the inner cell
Published in Gene Therapy Weekly, March 11th, 2004
According to published research from England, "peptide nucleic acids (PNAs) are effective antisense reagents that bind specific mRNAs preventing their translation. However, PNAs cannot cross cell membranes, hampering delivery to cells. To overcome this problem we made PNAs membrane-permeant by conjugation to the lipophilic triphenylphosphonium (TPP) cation through a disulphide bond."
"The TPP cation led to efficient PNA uptake into the cytoplasm where the disulphide bond was reduced, releasing the antisense PNA to block expression of its target gene," said A. Filipovska and...
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Source: Gene Therapy Weekly (2004-03-11)
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