Gene Therapy Vectors
RRV, SFV coat proteins suitable for lentivirus pseudotyping
Published in Gene Therapy Weekly, March 18th, 2004
RRV and SFV "are two alphaviruses that have a high degree of amino acid homology, as well as a very broad host range," virologists in the United States explained.
In a recent study, C.A. Kahl and colleagueas at Indiana University found that "envelope glycoproteins derived from both viruses can pseudotype human immunodeficiency virus type 1 (HIV-1)-derived lentivirus vectors."
"Both RRV and SFV glycoproteins considerably expand the host range of the lentivirus vector, and vectors can...
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Source: Gene Therapy Weekly (2004-03-18)
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