Published in Gene Therapy Weekly, March 18th, 2004
"A local increase in amyloid-beta peptide (Abeta) is closely associated with synaptic dysfunction in the brain in Alzheimer disease. Here, we report on the catabolic mechanism of Abeta at the presynaptic sites. Neprilysin, an Abeta-degrading enzyme expressed by recombinant adeno-associated viral vector-mediated gene transfer, was axonally transported to presynaptic sites through afferent projections of neuronal circuits," scientists writing in the Journal of Neuroscience report.
"This gene transfer abolished the increase in Abeta levels in the hippocampal formations of neprilysin-deficient...
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