Cardiology
Constructs targeting transforming growth factor-beta stop neointima formation
Published in Gene Therapy Weekly, March 25th, 2004
According to researchers in Japan, "we designed and synthesized a chimeric DNA-RNA hammerhead ribozyme targeting transforming growth factor (TGF)-beta1 mRNA and found that this ribozyme effectively and specifically inhibited growth of vascular smooth muscle cells. We examined the effects of the chimeric DNA-RNA hammerhead ribozyme targeting TGF-beta1 mRNA on neointima formation and investigated the underlying mechanism to develop a possible gene therapy for coronary artery restenosis after percutaneous transluminal coronary angioplasty. Expression of mRNAs encoding TGF-beta1, p27kip1, and...
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Source: Gene Therapy Weekly (2004-03-25)
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