Published in Gene Therapy Weekly, March 25th, 2004
"One of the hallmarks of cardiomyopathy and heart failure is pronounced and progressive cardiomyocyte death," scientists in Texas explained. "Understanding the mechanisms involved in cardiomyocyte cell death is a topic of great interest for treatment of cardiac disease."
"Mice null for desmin, the muscle-specific member of the intermediate filament gene family, develop cardiomyopathy characterized by extensive cardiomyocyte death, fibrosis, calcification, and eventual heart failure," noted N. Weisleder and colleagues at the Baylor College of Medicine. "The earliest ultrastructural...
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